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Хирургия и онкология

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Необходимо ли удаление бессимптомной первичной опухоли при нерезектабельном метастатическом раке толстой кишки?

https://doi.org/10.17650/2220-3478-2015-5-3-9-14

Аннотация

На момент постановки диагноза «рак толстой кишки» у трети пациентов выявляются отдаленные метастазы неоперабельного характера. Нередко первичная опухоль в толстой кишке имеет бессимптомное течение. Соответственно, перед хирургом и химиотерапевтом встает вопрос: удалять первичную опухоль или безотлагательно начинать химиотерапию (ХТ)? В условиях отсутствия результатов проспективных рандомизированных исследований, посвященных решению данного вопроса, необходимо рассмотреть все аргументы «за» и «против» удаления первичной опухоли: биологические особенности взаимоотношения первичной опухоли и метастазов, риск развития осложнений со стороны первичной опухоли в процессе ХТ, действует ли ХТ в равной степени на метастазы и на первичную опухоль, необходимо провести анализ ретроспективных исследований прогностического значения удаления первичной опухоли при наличии метастазов. Изучению данных аспектов и посвящен настоящий обзор литературы.

Об авторах

М. Ю. Федянин
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 23
Россия


А. А. Трякин
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 23
Россия


С. А. Тюляндин
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 23
Россия


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