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Хирургия и онкология

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ПАНИТУМУМАБ (ВЕКТИБИКС) В ТЕРАПИИ ХИМИОРЕЗИСТЕНТНОГО МЕТАСТАТИЧЕСКОГО РАКА ТОЛСТОЙ КИШКИ. РЕТРОСПЕКТИВНЫЙ АНАЛИЗ РЕЗУЛЬТАТОВ ЛЕЧЕНИЯ В ОТДЕЛЕНИИ ХИМИОТЕРАПИИ

https://doi.org/10.17650/2220-3478-2013-0-1-43-53

Аннотация

Представлены результаты лечения панитумумабом (вектибиксом) химиорефрактерного метастатического рака толстой кишки без мутации гена KRAS («дикий» тип) в отделении химиотерапии ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН. Высокая непосредственная эффективность (24,3 %) панитумумаба сопровождалась продолжительной выживаемостью без прогрессирования (медиана 4,71 мес), общая выживаемость в группе – 11,5 мес. При хорошей и предсказуемой переносимости лечения специфическая кожная токсичность ( II степени) препарата – значимый фактор прогноза эффективности вектибикса.

Об авторах

В. В. Бредер
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


В. А. Горбунова
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


Н. Ф. Орел
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


К. В. Орлова
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


А. Е. Кузьминов
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


Т. А. Борисова
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


Ю. В. Бисовская
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


И. Н. Гагарин
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


Н. Н. Мазуренко
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


В. В. Мочальникова
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


Е. Н. Холявка
ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, Москва
Россия


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