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Онкологическая колопроктология

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Иринотекан в лечении колоректального рака. Обзор литературы

https://doi.org/10.17650/2220-3478-2017-7-1-46-56

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Аннотация

С 1998 г. в арсенале онкологов появился принципиально новый противоопухолевый агент – иринотекан. С момента его одобрения в качестве препарата для проведения 2-й линии полихимиотерапии метастатического колоректального рака прошло уже 18 лет. За это время к применению иринотекана появилось большое количество показаний, его используют в различных сочетаниях с другими препаратами в качестве 1-й и 2-й линий терапии метастатического колоректального рака, в сочетании с таргетными препаратами и без, ведется ряд исследований по изучению работы препарата в неоадъювантном режиме. В статье рассматриваются история и современные схемы применения иринотекана в лечении колоректального рака.

Об авторах

В. А. Иванов
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России
Россия

Хирургическое отделение № 3 (онкопроктологии) Минздрава России; Россия, 115478 Москва, Каширское шоссе, 23



С. С. Гордеев
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России
Россия
Хирургическое отделение № 3 (онкопроктологии) Минздрава России; Россия, 115478 Москва, Каширское шоссе, 23


А. Б. Байчоров
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России
Россия
Хирургическое отделение № 3 (онкопроктологии) Минздрава России; Россия, 115478 Москва, Каширское шоссе, 23


В. А. Алиев
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России
Россия
Хирургическое отделение № 3 (онкопроктологии) Минздрава России; Россия, 115478 Москва, Каширское шоссе, 23


Д. В. Кузьмичев
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России
Россия
Хирургическое отделение № 3 (онкопроктологии) Минздрава России; Россия, 115478 Москва, Каширское шоссе, 23


А. В. Полыновский
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России
Россия
Хирургическое отделение № 3 (онкопроктологии) Минздрава России; Россия, 115478 Москва, Каширское шоссе, 23


А. О. Расулов
ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России
Россия
Хирургическое отделение № 3 (онкопроктологии) Минздрава России; Россия, 115478 Москва, Каширское шоссе, 23


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Для цитирования:


Иванов В.А., Гордеев С.С., Байчоров А.Б., Алиев В.А., Кузьмичев Д.В., Полыновский А.В., Расулов А.О. Иринотекан в лечении колоректального рака. Обзор литературы. Онкологическая колопроктология. 2017;7(1):46-56. https://doi.org/10.17650/2220-3478-2017-7-1-46-56

For citation:


Ivanov V.A., Gordeev S.S., Baychorov, A.B., Aliev V.A., Kuz’michev D.V., Polynovskiy A.V., Rasulov A.O. Irinotecan in the treatment of colorectal cancer. A literature review. Colorectal Oncology. 2017;7(1):46-56. (In Russ.) https://doi.org/10.17650/2220-3478-2017-7-1-46-56

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