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Тазовая хирургия и онкология

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Современные подходы к лечению местно-распространенного рака прямой кишки

https://doi.org/10.17650/2686-9594-2020-10-3-4-73-83

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Аннотация

Проведение неоадъювантной химиолучевой терапии с последующим выполнением тотальной мезоректумэктомии и адъювантной химиотерапией в течение 6 мес является стандартным алгоритмом лечения местно-распространенного рака прямой кишки (T3 или T4, и / или N1–2; M0) и в течение более 15 лет входит в практические рекомендации всех ведущих онкологических сообществ. Результаты опубликованных клинических исследований, посвященных изучению данной тематики, свидетельствуют о возможности использования более персонализированных терапевтических подходов, потенциально приводящих к улучшению отдаленных результатов противоопухолевого лечения и качества жизни пациентов. В этой работе мы представляем обзор имеющихся результатов клинических исследований, посвященных индивидуализации стандартного предоперационного лекарственного лечения и принципиально новым концепциям терапии местно-распространенного рака прямой кишки.

Об авторах

А. А. Качмазов
Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России
Россия

125284 Москва, 2-й Боткинский проезд, 3



Л. В. Болотина
Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России
Россия

125284 Москва, 2-й Боткинский проезд, 3



А. Л. Корниецкая
Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России
Россия

125284 Москва, 2-й Боткинский проезд, 3



Ю. Б. Карагодина
Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России
Россия

125284 Москва, 2-й Боткинский проезд, 3



И. В. Дрошнева
Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России
Россия

125284 Москва, 2-й Боткинский проезд, 3



А. А. Феденко
Московский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России
Россия

125284 Москва, 2-й Боткинский проезд, 3



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Для цитирования:


Качмазов А.А., Болотина Л.В., Корниецкая А.Л., Карагодина Ю.Б., Дрошнева И.В., Феденко А.А. Современные подходы к лечению местно-распространенного рака прямой кишки. Тазовая хирургия и онкология. 2020;10(3-4):73-83. https://doi.org/10.17650/2686-9594-2020-10-3-4-73-83

For citation:


Kachmazov A.A., Bolotina L.V., Kornietskaya A.L., Karagodina Yu.B., Droshneva I.V., Fedenko A.A. Novel approaches to treatment of locally advanced rectal cancer. Pelvic Surgery and Oncology. 2020;10(3-4):73-83. (In Russ.) https://doi.org/10.17650/2686-9594-2020-10-3-4-73-83

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